England's Matthew Baldwin, a member at Royal Birkdale, struck the opening shot of the championship. He teed off in the first group alongside Belgium's Thomas Detry and American James Nicholas.
Scheffler, who claimed last year's Open title at Royal Portrush with a 17-under-par total, is aiming to become the first back-to-back champion since Padraig Harrington retained the title in 2008, coincidentally at Royal Birkdale.
The American is scheduled to tee off at 9:58 a.m. local time alongside Bryson DeChambeau and England's Tyrrell Hatton.
Meanwhile, world number two Rory McIlroy will begin his challenge at 3:15 p.m. in a marquee group featuring defending champion Xander Schauffele and fellow Englishman Matt Fitzpatrick.
McIlroy is seeking a seventh major championship title and a second Open crown, having lifted the Claret Jug at Royal Liverpool in 2014.
South Africa has sent a strong contingent of eight players into the field, led by former champions Louis Oosthuizen and Ernie Els, and LIV star Branden Grace.
They are joined by the likes of Brandon Stone, Dylan Frittelli, Justin Harding, Shaun Norris, and rising talents such as Casey Jarvis, who earned his spot via the Investec South African Open.
The International team produced a stunning performance on day two of the Presidents Cup, sweeping all five foursomes matches to take a 7-3 lead over the United States at Medinah.
The Americans earned a narrow 3-2 lead over the International team after the opening day of the 16th Presidents Cup at Medinah Country Club on Thursday.
Brandt Snedeker has flexed the United States' muscles in choosing his opening pairings for the first session of the Presidents Cup at Medinah.
On the eve of the 2026 Presidents Cup, world number one Scottie Scheffler is the first person to acknowledge his rather poor record in team golf competitions.
